Systemic lupus erythematosus sle is a multisystem autoimmune disease that predominantly affects women of childbearing age. Klasifikasi sle sistemik lupus erithematosus ada 3 jenis penyakit lupus yang dikenal yaitu. Twentyfive male sle patients were evaluated for demographic. The samples were analyzed by manual count as well as by the computer assisted. Angka kejadian sle di dunia berkisar 22000 penduduk atau 1 penduduk. Genetic causes according to the national resource center on lupus, no less than 50 genes have been linked to lupus. Diffuse thinning or hair fragility with visible broken hairs with positive pulling test or apparent alopecia convincing the patient to ask for physician consultation. Pdf a case of systemic lupus erythematosis in a male presenting. Systemic lupus erythematosus sle is the prototypical autoimmune disease, characterized by an extreme variety of antinuclear antibodies and by different clinical presentations. Include cytoid bodies, retinal hemorrhages, serious exodate or hemorrhages in the choroids, or optic neuritis. Pdf systemic lupus erythematosus in the elderly researchgate.
Systemic lupus erythematosus is an autoimmune disease that affects many systems, including the skin, musculoskel etal, renal, neuropsychiatric, hematologic, cardiovascular, pulmonary. Physical activity and sedentary behavior in patients with. Doc systemic lupus erythematosus sle alifah f izzah. Menurut hasil penelitian lembaga konsumen jakarta lkj, pada tahun 2009 saja, di rs hasan sadikin bandung sudah terdapat 350 orang yang terkena sle sistemic lupus erythematosus.
Gejala utamanya adalah inflamasi kronis pada organorgan. Sle is a chronic disease of variable severity with a waxing and waning course, with signifi cant morbidity that can be fatalif not treated earlyin some patients fi gure 1. Sle sistemic lupus erythematosus adalah penyakti radang multisistem yang sebabnya belum diketahui, dengan perjalanan penyakit yang mungkin dapat akut dan kronik remisi serta eksaserbasi disertai adanya berbagai macam auto antibodi dalam tubuh. There has been improvement in survival, with the standardized mortality ratio in patients recruited to the toronto cohort in 19701977 being 10. Dinamakan lupus sistemik dikarenakan terjadi pada berbagai organ, terutama sendi, ginjal, dan kulit. Pediatric systemic lupus erythematosus american academy. Systemic lupus erythematosus, atau biasa disingkat sle adalah salah satu jenis penyakit lupus yang menyebabkan peradangan di hampir seluruh organ tubuh, seperti sendi, kulit, paruparu, jantung, pembuluh darah, ginjal, sistem saraf, dan selsel darah. Differences between male and female systemic lupus. Dilaporkan bahwa pada pasien sle di eropa, manifestasi klinis terbanyak berturutturut adalah artritis sebesar 84%, ruam malar 58%, demam 52% sedangkan manifestasi klinis yang jarang dijumpai adalah ruam diskoid 10 %, anemia hemolitik 8%, lesi.
Systemic lupus erythematosus sle is a clinically heterogeneous disease which is autoimmune in origin, and characterized by the presence of autoantibodies directed against nuclear antigens. Sle and aps frequently occur within the same patient. Lupus merupakan penyakit yang terkait dengan kekebalan tubuh manusia. The diagnosis and treatment of systemic lupus erythematosus. Systemic lupus erythematosus is an autoimmune disease that affects many systems, including the skin, musculoskel etal, renal, neuropsychiatric, hematologic, cardiovascular, pulmonary, and. Systemic lupus erythematosus sle, also known simply as lupus, is an autoimmune disease in which the bodys immune system mistakenly attacks healthy tissue in many parts of the body. A clinical overview of systemic lupus erythematosus in childhood. Systemic lupus erythematosus sle is a chronic systemic autoimmune disease. Lupus is a chronic autoimmune condition that causes inflammation throughout your body. Longterm prognosis and causes of death in systemic lupus. One of us has likened the existence of a distinct male lupus. The 4 types of lupus are systemic lupus erythematosus sle, cutaneous lupus, druginduced lupus, and neonatal lupus. Systemic lupus erythematosus genetics home reference nih. Systemic erithematosus lupus sel atau yang biasa dikenal dengan istilah lupus adalah penyakit kronik atau menahun.
Slicc, systemic lupus international collaborating clinicsamerican college of rheumatology damage index. Systemic lupus erythematosus is a systemic autoimmune disease with a worldwide distribution. Pdf onset of the disease above the age of 65 years is unusual. Systemic lupus erythematosus knowledge for medical. Although both men and women of all age groups can be affected, women outnumber men. Pdf luaran kehamilan dengan sistemik lupus eritematosus. Although 5 yr after diagnosis 92% of patients are alive, the prognosis falls to 82% survival at 10 yr, 76% at 15 yr and only 68% at 20 yr in toronto. Causes of lupus or systemic lupus erythematosus sle. The condition is much more than a positive antinuclear antibody ana. Th e figure 1 natural history of systemic lupus erythematosus. Pemeriksaan imunologi tersebut merupakan salah satu kriteria dalam penentuan diagnosis sle. Clinical and pathological characteristics of male patients with. Penyakit systemic lupus erythematosus sle adalah salah satu penyakit yang terkait dengan sistem imun. Sle sistemisc lupus erythematosus adalah penyakti radang multisistem yang sebabnya belum diketahui, dengan perjalanan penyakit yang mungkin akut dan fulminan atau kronik remisi dan eksaserbasi disertai oleh terdapatnya berbagai macam autoantibodi dalam tubuh.
Perkembangan penyakit lupus meningkat tajam di indonesia. Antiphospholipid syndrome aps is characterized by the presence of arterial or venous thrombosis and antiphospholipid antibodies. The most common form of lupus is systemic lupus erythematosus sle, the causes of which are detailed below. Ada banyak sekali penyakit autoimun, dan salah satunya adalah sistemik lupus eritematosus atau disingkat sle. Symptoms vary between people and may be mild to severe. Successful percutaneous coronary intervention in a young male. Systemic lupus erythematosus, the most common form of lupus, is a chronic autoimmune disease that can cause severe fatigue and joint pain. Komplemen adalah senyawa dalam darah yang membentuk sebagian sistem kekebalan tubuh. Sle, outcome measures, lupus nephritis, male gender. Namun, kondisinya bisa dikontrol secara efektif tanpa flareup dengan. Systemic lupus erythematosus sle adalah penyakit kronik autoimun di mana badan pesakit menghasilkan protein darah dengan banyaknya.
Systemic lupus erythematosus sle, is the most common type of lupus. Memahami patogenesis sle dan patofisiologi sle penting agar penatalaksanaan penyakit ini dapat berlangsung dengan baik. An inflammatory autoimmune disease that affects the functions of many different biological systems and occurs when the body creates antibodies that attack its own tissue. Systemic lupus erythematosus sle is still a disease with significant mortality.
Systemic lupus erythematosus sle is an auto immune disease that affects multiple organs and result in significant morbidity and mortality. Male sle patients in ghana are comparable to other populations, with arthritis and constitutional features being predominant early features and lupus nephritis. Banyak faktor yang memengaruhi terjadinya kasus sle di indonesia, antara lain belum terpenuhinya kebutuhan pasien dan keluarganya tentang informasi, pendidikan, dan dukungan yang terkait dengan sle. Systemic lupus erythematosus sle is a chronic autoimmune disease that can involve any organ system with a wide range of disease manifestations, and can lead to significant morbidity and even mortality. The unexplained female predominance of systemic lupus. Sle, but longterm prognosis remains poor in patients with severe sle manifestations. Lupus erythematosus le terdiri dari systemic lupus erythematosus sle dan discoid lupus erythematosus dle. Di indonesia belum diketahui angka pastinya, tetapi di rsu dr. Lp asuhan keperawatan pasien dengan sle systemic lupus. Kondisi pasien mungkin berfluktuasi dan berakibat fatal jika tidak segera diobati saat berkobar. Tugas mata kuliah patologi tentang penyakits ystemic lupus erythematosus sle. Di antaranya adalah antidsdna antibody, antism antibody, antiphospholipid antibody, syphilis, lupus anticoagulant, dan coombs test. Common symptoms include painful and swollen joints, fever, chest pain, hair loss, mouth ulcers, swollen lymph nodes, feeling tired, and a red rash which is.
Systemic lupus erythematosus sle is a chronic disease that causes inflammation in connective tissues, such as cartilage and the lining of blood vessels, which provide strength and flexibility to structures throughout the body. Sistemic lupus erythematosus sle astriwidia87s blog. Reproductive health in male systemic lupus erythematosus scielo. Seperti kita ketahui sle atau systemic lupus erythematosus adalah penyakit autoimun yang dicirikan dengan hilangnya toleransi sistem imun terhadap komponen self antigen akibat autoantibodi yang merusak jaringan atau organ tubuh. Sle termasuk penyakit collagenvascular yaitu suatu kelompok penyakit yang melibatkan sistem muskuloskeletal, kulit, dan pembuluh darah yang mempunyai banyak manifestasi klinik sehingga diperlukan pengobatan yang kompleks. Tanda dan gejala penyakit ini dapat bermacammacam, dapat bersifat sementara, dan sulit untuk didiagnosis. Iraj salehiabari 2015, 2015 acrslicc revised criteria for diagnosis of systemic lupus erythematosus. Penyakit sle masih tergolong penyakit yang awam di indonesia. Berbeda dengan dle yang hanya akan menunjukkan manifestasi pada kulit, sle merupakan tipe le yang juga dapat menunjukkan manifestasi pada organ tertentu selain pada kulit. Sle is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. Penyakit ini berhubungan dengan deposisi autoantibodi dan kompleks imun, sehingga mengakibatan kerusakan jaringan. The exact cause is still unknown, but hormonal and immunological influences as well as genetic predisposition are considered likely etiological factors. Systemic lupus erythematosus and antiphospholipid syndrome.
Asuhan keperawatan systemics lupus erythematosus sle andi jumriani joseph 9312910105024 stik avicenna butta toa bantaeng 2015 bab i pendahuluan latar belakang systemic lupus erytematosus sle atau lupus eritematosus sistemik les adalah penyakit radang atau inflamasi multisistem yang penyebabnya diduga karena adanya perubahan sistem imun albar, 2003. Systemic lupus erythematosus in children and adolescents. Sle adalah jenis lupus yang paling sering dialami orang. The clinical course is variable, with a broad spectrum of organ manifestations. Istilah lupus erythematosus pernah digunakan pada zaman yunani kuno untuk menyatakan suatu penyakit kulit kemerahan di sekitar pipi yang disebabkan oleh gigitan anjing. Penyakit terjadi apabila terjadi anomali pada sistem dan kerja sel pertahanan tubuh manusia. Soetomo angka kejadian sle dengan penderita baru terdiagnosis sekitar 40 kasus perbulan, dengan manifestasi organ yang beragam, mulai dari yang ringan hingga mengancam jiwa. Systemic lupus erythematosus sle is a chronic, multisystem, autoimmune disease characterized by periods of increased disease activity caused by inflammation of blood vessels and connective tissue. Lupus eritematosus sistemik wikipedia bahasa indonesia. Karena itu angka yang pasti tentang jumlah orang yang terserang oleh penyakit ini sulit untuk diperoleh. It is, by definition, a multisystem disease, and patients can present in vastly different ways. Protin darah yang dipanggil antibodi ini dengan sendirinya memberi tindak balas terhadap tisu seseorang. Discoid rash raised erythematous patches with keratotic scaling, follicular plugging, and atrophic scarring 3. Manifestasi klinis sle sangat luas, meliputi keterlibatan kulit dan mukosa, sendi, darah, jantung, paru, ginjal, ssp dan sistem imun.
Acute myocardial infarction ami is an uncommon initial. Effect of gender on clinical presentation in systemic lupus. The samples were analyzed by manual count as well as by the computerassisted. Sel pertahanan tubuh yang seharusnya melindungi tubuh dari masuknya kuman atau gangguan eksternal lainnya justeru menyerang tubuh pemiliknya. The signs and symptoms of sle vary among affected individuals, and can involve many organs and systems, including the skin, joints, kidneys, lungs, central nervous. Hal ini disebabkan oleh manifestasi penyakit yang sering terlambat diketahui sehingga berakibat pada pemberian terapi yang inadekuat, penurunan. Male patients with systemic lupus erythematosus sle are thought to be similar to female patients with sle, but key clinical characteristics may. Pdf on jan 12, 2015, hm a edirirweera and others published a case of systemic lupus erythematosis in a male presenting as chronic headache find, read. Learn about the symptoms, causes, risk factors, treatment options, and more. Despite recent progress in the understanding of systemic lupus erythematosus sle, the striking 9.
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